View source for High-conductance state

==== Modulation of intrinsic neuronal properties ====

Synaptic noise affects neuronal responsiveness, but what happens when
neurons express dominant intrinsic properties, such as bursting ?
This question was addressed so far only for thalamic neurons (Wolfart
et al., 2005).  This study revealed that the classic "tonic" and
"burst" modes of firing in thalamic relay cells were profoundly
altered.  With synaptic noise, these modes are no longer
distinguishable because bursts and single-spikes participate to all
responses.  It was also shown that strong K+ conductances can change
the sign of gain modulation in cortical neurons (Higgs et al., 2006).
How extrinsic noise interacts with intrinsic neuronal properties is
at present only very partially understood, and should be investigated
by future studies.