Adult neurogenesis/neurogenesis table

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    Many factors have been shown to affect the levels of neurogenesis in the adult brain. Most of these affect one of two processes: 1> the proliferation of precursor or stem cells and 2> the survival of immature neurons. It is possible that other processes can be affected as well.

    For detailed descriptions and references, see Ming and Song, 2005 and Abrous et al., 2005.

    Dentate Gyrus

    Regulator Effect Target Process
    Genetic Background Increase/Decrease Proliferation & Survival
    Enriched Environment Increase Survival
    Physical Exercise Increase Proliferation
    Learning Increase Survival
    Aging Decrease Proliferation
    Dietary Restriction Increase Survival
    Stress Decrease Proliferation
    Seizure Activity Increase Proliferation & Survival
    Ischemia Increase Proliferation & Survival
    Irradiation Decrease Proliferation & Survival
    Alzheimer’s Disease Unknown Proliferation
    Huntington’s Disease Decrease Proliferation
    Parkinson’s Disease Decrease Proliferation
    Opiates Decrease Proliferation
    Antidepressants Increase Proliferation & Survival
    Ethanol Decrease Proliferation (?) & Survival

    Olfactory Bulb

    Regulator Effect Target Process
    Enriched Odor Environment Increase Survival
    Physical Exercise No change
    Odor Learning Increase Survival
    Aging Decrease Proliferation
    Dietary Restriction No change
    Seizure Activity Increase Proliferation & Survival
    Ischemia Increase Proliferation & Survival
    Irradiation Decrease Proliferation & Survival
    Alzheimer’s Disease Increase Proliferation
    Huntington’s Disease Increase Proliferation
    Parkinson’s Disease Decrease Proliferation & Survival
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